Flights from Des Moines to San Francisco from $ 399*

Promotion Code

Changed bag rules and optional services         Cruise Packages

Featured daily fares for flights from Des Moines (DSM) to San Francisco (SFO)

Mar 2026
From$ 579*
Viewed: 1 day ago
RoundTrip|Economy
Apr 2026
From$ 419*
Viewed: 1 day ago
RoundTrip|Economy
May 2026
From$ 399*
Viewed: 1 hour ago
RoundTrip|Economy
$ 419
$ 1.0K
Displaying fares for March-2026
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    • Range$ 419-$ 1,027

    *Prices have been available for round trips within the last 48 hours and may not be currently available. For Economy class, fares listed may be Basic Economy, which is our most restrictive fare option and subject to additional restrictions. Additional baggage charges and fees for other optional service may apply. Other terms and conditions may apply. Schedules are subject to change without notice.

    More United deals on Des Moines (DSM) to San Francisco (SFO) flights

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    More United deals on Des Moines (DSM) to San Francisco (SFO) flights
    From
    To
    Fare Type
    Dates
    Price
    Des Moines (DSM)San Francisco (SFO)Roundtrip
    |
    Economy    		05/04/26 - 05/16/26

    from

    $ 399

    Viewed: 1 hour ago

    Des Moines (DSM)San Francisco (SFO)Roundtrip
    |
    Economy    		06/02/26 - 06/09/26

    from

    $ 419

    Viewed: 1 day ago

    Des Moines (DSM)San Francisco (SFO)Roundtrip
    |
    Economy    		06/03/26 - 06/10/26

    from

    $ 419

    Viewed: 1 day ago

    Des Moines (DSM)San Francisco (SFO)Roundtrip
    |
    Economy    		05/02/26 - 05/05/26

    from

    $ 419

    Viewed: 1 day ago

    Des Moines (DSM)San Francisco (SFO)Roundtrip
    |
    Economy    		05/09/26 - 05/12/26

    from

    $ 419

    Viewed: 1 day ago

    Des Moines (DSM)San Francisco (SFO)Roundtrip
    |
    Economy    		05/27/26 - 06/03/26

    from

    $ 419

    Viewed: 1 day ago

    Des Moines (DSM)San Francisco (SFO)Roundtrip
    |
    Economy    		05/02/26 - 05/06/26

    from

    $ 419

    Viewed: 1 day ago

    Des Moines (DSM)San Francisco (SFO)Roundtrip
    |
    Economy    		05/04/26 - 05/11/26

    from

    $ 419

    Viewed: 1 day ago

    *Prices have been available for round trips within the last 48 hours and may not be currently available. For Economy class, fares listed may be Basic Economy, which is our most restrictive fare option and subject to additional restrictions. Additional baggage charges and fees for other optional service may apply. Other terms and conditions may apply. Schedules are subject to change without notice.

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