Flights from Des Moines to Mexico from $ 429*
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1 Passenger, Economy
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Find United's best fares from Des Moines to Mexico
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Des Moines (DSM)to
Cancun (CUN)12/13/25 - 12/17/25from$Â 429Viewed: 22 hours agoRoundtripEconomy
Des Moines (DSM)to
Cabo San Lucas (SJD)03/04/26 - 03/11/26from$Â 466Viewed: 22 hours agoRoundtripEconomy
Des Moines (DSM)to
Puerto Vallarta (PVR)12/31/25 - 01/14/26from$Â 561Viewed: 22 hours agoRoundtripEconomy
Des Moines (DSM)to
Ixtapa-Zihuatanejo (ZIH)01/21/26 - 01/28/26from$Â 569Viewed: 22 hours agoRoundtripEconomy
*Prices have been available for round trips within the last 48 hours and may not be currently available. For Economy class, fares listed may be Basic Economy, which is our most restrictive fare option and subject to additional restrictions. Additional baggage charges and fees for other optional service may apply. Other terms and conditions may apply. Schedules are subject to change without notice.
Business class flights from Des Moines to Mexico
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Des Moines (DSM)to
Cancun (CUN)
01/17/26 - 01/22/26
Roundtrip
Business
from
$Â 785
Viewed: 21 hours ago
Des Moines (DSM)to
Cabo San Lucas (SJD)
02/15/26 - 02/19/26
Roundtrip
Business
from
$Â 1,138
Viewed: 2 hours ago
Des Moines (DSM)to
Puerto Vallarta (PVR)
01/17/26 - 01/21/26
Roundtrip
Business
from
$Â 923
Viewed: 1 hour ago
*Prices have been available for round trips within the last 48 hours and may not be currently available. For Economy class, fares listed may be Basic Economy, which is our most restrictive fare option and subject to additional restrictions. Additional baggage charges and fees for other optional service may apply. Other terms and conditions may apply. Schedules are subject to change without notice.